Combine 1 bottle hot pepper sauce, 1/2 cup butter, Worcestershire sauce, oregano, onion powder, and garlic powder in a saucepan over medium heat. Bring mixture to a boil, reduce heat to low, and simmer for 5 minutes.
Place chicken wings into slow cooker and pour sauce mixture over wings.
Cook on High for 2 hours. Reduce heat to Low; cook 2 hours more.
Preheat oven to 400 degrees F (200 degrees C). Grease several baking sheets.
Spread wings onto prepared baking sheets and bake in preheated oven until wings are crisp and browned, about 30 minutes.
Melt 1/2 cup butter with 1 bottle hot sauce in a small saucepan and simmer until thickened, about 20 minutes. Brush sauce onto wings just before serving.
