Preheat the oven to 350 degrees F (175 degrees C). Spray a baking dish with cooking spray.
Place tilapia pieces into the prepared baking dish. Combine bread crumbs, parsley, lemon zest, and garlic powder in a small bowl. Mix in melted butter and sprinkle mixture over fish fillets.
Bake in preheated oven until tilapia flakes easily with a fork, about 15 minutes.
