Preheat the oven to 350 degrees F (175 degrees C).
Combine Cheddar cheese and mayonnaise; refrigerate.
Mix ground beef, salt, pepper, Creole seasoning, onion powder, and garlic powder together. Form mixture into 12 slider patties; place on a baking sheet.
Bake patties in the preheated oven, flipping once, for about 15 minutes. Remove from oven and top each patty with 1 tablespoon of the cheese-mayonnaise mixture. Continue baking until cheese has melted, 1 to 2 minutes more. Serve on slider buns.
